Topical Chemotherapy
Topical chemotherapy uses prescription-strength creams applied directly to the skin to eliminate precancerous cells and certain superficial skin cancers at the surface level. It’s a clinically proven, dermatologist-guided approach that most patients complete at home over the course of several weeks.
What Is Topical Chemotherapy?
When most people hear "chemotherapy," they think of infusions given in an oncology clinic, a very different experience from what is described here. Topical chemotherapy, as used in dermatology, refers to prescription creams applied directly to the surface of the skin to destroy precancerous or cancerous cells locally. There are no IV lines, no hospital visits, and no systemic side effects associated with traditional cancer chemotherapy.
The most commonly prescribed topical chemotherapy agents in dermatology are 5-fluorouracil (5-FU), available under brand names including Efudex and Carac, and imiquimod (Aldara and Zyclara). Both work by interfering with the growth of abnormal cells at the skin's surface. 5-FU blocks the cellular processes that allow abnormal cells to replicate. Imiquimod works differently, stimulating the immune system to recognize and attack abnormal tissue.
Your dermatologist will prescribe the appropriate medication, concentration, and application schedule based on your specific diagnosis and the area being treated. The treatment course typically spans several weeks and is managed at home, with follow-up visits to monitor your response and confirm resolution.
What to Expect With Topical Chemotherapy?
Unlike in-office procedures, topical chemotherapy is a multi-week treatment managed primarily at home. Here is how the process works from your first consultation through the end of your treatment course.
Consultation and Diagnosis
Prescription and Instructions
At-Home Application
Inflammatory Response
Follow-Up Monitoring
End of Treatment and Healing
What to Expect During and After Your Treatment Course
Topical chemotherapy does not follow a single-day recovery arc; it unfolds over weeks, with the most visible skin reaction occurring mid-treatment before healing begins. The timeline below reflects the general course of a standard treatment regimen. Your provider will give you a specific schedule based on your diagnosis and the medication prescribed.
Recovery At A Glance
Nationally Recognized Leaders in Skin Cancer Care
Guidance That Extends Beyond the Office Visit
The Full Spectrum of Skin Cancer Treatment in One Network
Dermatologists Who Treat the Whole Picture
What Patients Are Saying
Roger B.
Great.
KAthleen L.
There is professionalism and excellent customer service from the time you enter. I love my doctor and her assistant. They make me feel like family and not just a patient.
Buzz A.
I have been there twice and had numerous spots treated. They have always handled a lot of questions nicely for me and I appreciate them! The location is a little hidden across the street from the Lithia Pinecrest Publix store if you want to drop someone off while you’re at your appointment.
Charles R.
Dr Matthew Katz and staff are the best! Professional and friendly. I've been going to the practice for years and still make the 50 minute trip from Annapolis regularly.
Susan E.
I love Rock Creek Dermatology! I spent most of my life in California and have had multiple issues with skin cancer. I am so happy to have found a professional, knowledgeable, caring and pleasant group right here in Urbana. I highly recommend them !
Dwayne C.
Friendly staff and excellent service
Steve J
Great experience with Dr. Echt’s staff - Kelsey and Suzanne (PA) they were both very friendly and professional, gave me opportunities to ask questions. This was my second visit easy to get an appointment and waited less than 5 minutes in the waiting room. Beautiful facility and recommending Dr. Echt to my wife and daughters.
Juana M.
El lugar super limpio, ordenado y ambiente agradable, el tiempo de espera es mínimo y la atención es excelente, la chica del front desk es muy amable, lo recomiendo .
Julia B.
The nurse practitioner was honest with me and did not try to upsell me into biopsying my mole of concern. She was straight up that the cancer risk was low, while she could not guarantee it was cancer free. I appreciated the transparency.
Diane B.
Everyone one in this office is so kind and welcoming. Dr. Harvey is the best plastic surgeon!!! And dermatologist so is his assistant! They're all a team and the very best at what they do!! Love them!
Hunter P.
Great experience. Location is easy to get to and comfortable inside. Staff was very nice and welcoming. Good music playing (does that matter for a dermatologist? Maybe not, but I liked it!) I was seen quickly and my questions/concerns were addressed in a way that was reassuring and informative. Felt listened to and properly attended to.
Charletta
My first visit was very good.
Roseanne C.
I made an appointment with Morgan to have a spot on my leg checked. She examined the area and found that there was nothing wrong. I was definitely relieved. I highly recommend this practice!
Turbo M.
Very Courteous, Friendly, Timely and Professional Staff! Treated With Kindness!
Wendy D.
Scheduling the appointment was super quick and easy. As a new patient I anticipated it would be a few weeks wait to be seen but to my surprise they had availability as soon as a day ahead. I scheduled a skin check with Dr. Francis who ended up freezing a spot and sending another one to pathology. She took her time and genuinely listened to my concerns. Furthermore she noticed my lips were chapped (chronic dry lips) and she recommended a OTC medicated chapstick which she also offered me samples of. 100% would return to the West Largo location :) Office was clean and the receptionist was friendly too.
David R.
Every body in that center are professional. I feel so comfortable whenever I go there. Doctor Smith is my doctor and he is the best 👌.
Karen J.
Dr. Zook and his team are the best at what they do. He is my guardian angel and monitors my skin on a regular basis.
Ken C.
Pleasant experience - clean and professional
thomas g.
very good excellent.
Lisa E.
Been a patient of AAD for years. Just was switched to a new physician. I am very happy.
Lisa E.
The practice was professional, listened to my concerns, and we decided together what the best direction we should move forward doing.
Lisa E.
Long standing pt of Dr Rice and her PA. Always a great experience with either of them.
Lisa E.
The doctor/staff are professional and polite . And the facility is very clean. My wait time was less than 10 minutes.
Lisa E.
Paige is the best!!!
Lisa E.
I highly recommend this practice. I use PA Nicole Fuller. She was very professional and explained everything that she did her Nurse. Jen was equally as knowledgeable. They both were very compassionate and caring.
Lisa E.
I had my third BBL appt of three. After the second one, a bunch of new brown spota emerged which were shocked again. It's finally starting to crust up and fall off leaving normal looking skin. I recommend.
Lisa E.
Everyone was very knowledgeable and extremely helpful. I feel very comfortable with everything that they have recommended for my treatment.
Lisa E.
I got my first BBL from Ashley and she did amazing! I am so impressed with the results. I’ll definitely be back.
Lisa E.
I’ve had a great experience with Dr. Ismail! She’s always thorough, takes the time to listen, and gives thoughtful recommendations. She even went out of her way to accommodate me and fit in an additional treatment despite having a packed schedule. I really appreciate how caring and attentive she is. Highly recommend her!
Lisa E.
Dr Germanas was very professional and friendly and listened attentively to all my concerns I wld recommend this practice
Lisa E.
My son had an excellent experience with dermatologist (Dr. K ) and Lillian. From the moment we walked in, the staff was welcoming, professional, and efficient. Dr. K took the time to carefully listen to our concerns, thoroughly explain my son’s condition, and discuss all available treatment options in a clear and reassuring way. I truly appreciated how knowledgeable and attentive they were. I never felt rushed during my appointment, and all my questions were answered with patience and care. The treatment plan has been very effective, and I’ve already seen noticeable improvement. I highly recommend this dermatologist to anyone looking for expert care in a comfortable and supportive environment. Felicia Thomas
Lisa E.
Best dermatology group in our area. Have been going here for years and recommend them to all my friends!
Lisa E.
I found Dr Smith to be excellent the whole staff very professional it's a fourth time I've been there I'm very pleased with everybody
Lisa E.
Dr. Clarke was extremely kind and took the time to answer all my questions clearly and thoroughly. I genuinely appreciated her professionalism and compassionate care. I highly recommend her to anyone seeking an excellent doctor!
Lisa E.
Excellent customer service. Very satisfied with the treatment for my skin problem. Great results!
Lisa E.
Everyone from Reception to Nurses and Dr’s were kind and courteous. They went out of their way to explain the process to me and made sure I was comfortable. Highly recommend
Lisa E.
Friendly office. I was able to get an appointment with my doctor promptly and am happy my treatment by Dr. Sable.
Lisa E.
I had an issue with a concerning very dark mole. I easily made an appt for the next day! Semhar was delightful, caring, and responded to my issues quickly. She thoroughly explained everything. As retired nurse practitioner, I’m always willing to see an NP!
Lisa E.
Very friendly and efficient.
Lisa E.
From front staff to Drs and nurses, five stars all the way around
Lisa E.
Awesome service, great atmosphere!
Lisa E.
I was thoroughly impressed with the service I received during a recent visit. I was skeptical at first based on the reviews. I was greeted by a welcoming front desk staff, and Nathali Rodriguez, PA answered my questions and provided insightful information regarding my skincare. She was attentive, professional, and demonstrated exceptional bedside manner. I'll definitely return for future treatment!
Lisa E.
This dermatologist takes great care in looking for skin Cancer and treatment. I highly recommend this office.
Lisa E.
Great experience with all the staff. Dr. Dawn took the time to answer all my many questions. Her assistant was also very helpful. Will definitely recommend this practice and return.
Lisa E.
Great experience. Very convenient location. Dr. Suarez was awesome and answered all of my questions. Would highly recommend this office.
Lisa E.
Doctor Malone performed Mohs surgery on the right side of my neck in early FY 2026 to treat a large patch of basal cell carcinoma. She did an absolutely amazing job, top notch, strongly recommend!
Lisa E.
Best dermatology clinic. Friendly, clean, and professional care.
Lisa E.
Highly recommend Dr Dhar. He is caring and finds everything!!!
Lisa E.
I always love coming here. The staff is very respectful and they listen well. It’s very hard to find a dermatologist that works well with darker skin and these guys excel!
Lisa E.
Saw new practitioner, Caitlan, and was very pleased with her knowledge and bedside manner.
Lisa E.
Dr. Jennifer Gamber is Amazing!! Very Professional, Friendly, Very Thorough, Very Knowledgeable!! She has been my Dermatologist for many, many years!! I trust her! Her staff are very professional, friendly and caring! The office is very clean! They have a Mohs Surgery Center there as well!! They also have a skin spa suite there as well! I recommend Anne Arundel Dermatology very much so!! They're Great!!
Lisa E.
love doctor Childress, everyone is great,and they don't make you wait very long at all once you go back, like a lot of other doctor office
Lisa E.
Dr. James Martin is the BEST! I cannot say enough wonderful things about our experience with him and the entire office! Amazing all around. We drive a long way from home to see him. My daughter loves him. He is a wonderful listener and very intelligent.
Lisa E.
Appointment went smoothly everyone was friendly and wait time was fast.
Lisa E.
Dr. Dudkiewicz did the best for me. She explained what I need to get done so I can stay young and beautiful. I felt so comfortable and I will definitely go back
Lisa E.
I can’t say enough great things! I’ve received Botox, Microneedling, Hydrafacials, Filler, and multiple laser treatments from Brittany Conrad over the last few years. She’s super knowledgeable and amazing at what she does!
Lisa E.
I transferred to this office from Advanced Dermatology. Couldn't be happier. The location is great & the office itself has a retro vibe. It's easier to get an appointment here & it's a fun place to be. Plus: Roswell!
Lisa E.
Very professional and polite! Took care of issues with minimal waiting
Lisa E.
Absolutely loved my visit at Dermatology Institute today. From the front desk all the way to Dr. Jamie and her man nurse don’t know his name but he was so funny!!!🤭 Everybody was very nice and pleasant! see yall again in 6 months!!!
Lisa E.
The clinician was professional & personable,,,And, Dr Chalgrin is simply the best… Sincerely
Lisa E.
My first visit, everyone was friendly and smiling. This is a good sign that the staff cares. I would highly recommend them to anyone
Lisa E.
I am very satisfied with the care I received at AAD in Countryside. The assistant was caring and friendly. The Doctor was thorough and professional. I felt that they had my good health in mind for all they did for me. The location is also convenient for me with plenty of parking. My wait time was minimal and the check-in was fast. I was in and out in no time.
Lisa E.
Always have good experiences with Dr. Cook. He goes over his diagnosis with you and explains your options. Very knowledgeable and alway prompt for appointments.
Lisa E.
Great job today.
Lisa E.
Very professional on time Melissa goes above and beyond to help patients
Lisa E.
Highly recommend,kind and nice staff,doctor take time to answer all questions and concerns,clean office,nurse,front desk and all staff very nice and professional
Lisa E.
Everyone in the office was very professional, courteous and friendly. Dr Niebyl was on time and thorough in explaining my condition and proposed treatment. I would highly recommend their services to anyone who needs it
Lisa E.
I have only had positive experiences with Kelly Barriault PA-C. I have to be seen every 6 months because I have a lot of freckles. Skin cancer is no joke!
Lisa E.
I have been going to Anne Arundel Dermatology for several years for routine care with Lisa Laumann, who is terrific. After a biopsy I was found to have cancer, and had MOHS surgery yesterday with Dr. Dolan at their surgical center in Annapolis. The care from everyone there, from start to finish, was superb despite how busy they were. I highly recommend AAD for anyone with dermatological issues. Thanks!
Lisa E.
Kayla is amazing, I send everyone who needs a dermatologist to her. So knowledgeable and caring!
Lisa E.
I had a great experience with dr Kenny and Taylor! The medical assistant was so patient and kind and answered any questions I had. Kenny made sure I was listened to and I look amazing!! Highly recommend
Lisa E.
I had an amazing visit here. Great reception from Ms. Bethllhem and Ms. Shadra with lots of smiles. Dr. James was phenomenal and had my procedure done with a minute. Get here on time and you'll be through an easy process with ease. You must visit here. It's definitely a 5 star.
Lisa E.
Dr Miller is great. Listens to all concerns and addresses them. Went in for a scar check from Mohs surgery and also had another problem and both was taken care of with no question.
Lisa E.
I’ve been a patient of Dermatology Specialists of Warrington for years and remained with them through their transition period. This “new” office is a gift. Cassandra Cohen and her entire staff are kind, patient and incredibly knowledgeable, always providing me with an experience in which I feel calm, comfortable and, most importantly, valued. Their high level of professionalism and thoroughness is exceptional and it is something I do not take for granted. They’re special, this group. And I’m so incredibly happy for all of them.
Lisa E.
Great people, great atmosphere and wonderful doctor.
Lisa E.
I love each one at the dermatologist they are my second family! And was surprised to walk into the room and they had a mini pound cake 🍰 waiting on me because it was my birthday love you kids!
Lisa E.
I think that this office staff is very friendly and helpful. Thanks for caring about my health. My Wife was worried about me and the Dermatologist checked out my back and brought us piece of mind.
Lisa E.
Mellisa is the kindest and most knowledgeable medical professional i have met. The front desk receptionist is also exceptionally helpful.
Lisa E.
Excellent example of a well run office. Staff friendly and efficient. Dr. O’Neill was kind and expert.
Lisa E.
Aubrey is the best!! I want to keep her to myself but I also want to shout out how amazing she is!
Lisa E.
Great people, they are there with you all the way, diagnose and treatment. They pull out all stops to get you the medication needed at an affordable price.
Lisa E.
Kind, caring professional staff. Always take the time to answer questions and assist in any way needed.
Lisa E.
Outstanding from start to finish.
Lisa E.
Friendly and informative. Went in for my first peel, great results.
Lisa E.
All the staff are great 👍🏻..
Lisa E.
Dr. Sonya is very attentive and caring! Thank you very much! The best service!
Lisa E.
Charu, Sandra, and Claire are an extremely talented and well-educated group of cosmetic providers that will undoubtedly impress you with their passion and knowledge of aesthetic treatments. I have had the chance to have treatments done by each of them -- a full face BBL with Charu, Botox with Sandra, and filler with Claire. Every treatment has exceeded my expectations in terms of comfort and results. This new office is modern, spacious, and conveniently located. I highly recommend checking them out!
Lisa E.
This place was awesome and the staff was amazing!
Lisa E.
Dr. Suarez is terrific. She is thorough, knowledgeable and empathetic. I will certainly recommend her to any friends who need a dermatologist.
Lisa E.
My experience was quite pleasant, my concerns were listened to, with compassion and addressed, accordingly. The office staff was welcoming, friendly, and very professional. I highly recommend this office.
Lisa E.
Patrice was kind, professional, and truly listened to my concerns. Dr. Callaway did an outstanding job explaining my treatment plan and ensuring I received excellent care. I was very impressed with everyone at DSA and had a wonderful experience from start to finish. ⭐️⭐️⭐️⭐️⭐️
Lisa E.
I genuinely had the most positive experience here. I drove to the wrong location and the lovely lady at the front desk worked with me and managed to squeeze me in with a PA. The PA was wonderful and took her time with me even though I wasn’t supposed to be there. Lovely group
Lisa E.
Dr Germanus and staff always are professional and you feel at ease when in their presence.
Lisa E.
Sarah did her magic once again. The front desk staff are awesome!
Lisa E.
Courteous and knowledgeable staff!
Lisa E.
Thanks to Dr Brian Connolly and his team, I am so much better. My best in and out surgery procedure that I can remember. Thank you so much 😊
Lisa E.
I had an excellent experience with AA Dermatology Berlin. The office staff was helpful and friendly. I was seen promptly and Paige was thorough and informative and pleasant, and she answered all my questions.
Lisa E.
In one word....superb! The practice is a model of what superior medical practice should like. Wish there were more of the same.
Lisa E.
Great experience!
Lisa E.
Phonimanal medical service! The best dermatology practice anywhere in Tampa.
Lisa E.
Atlantic Dermatology is always efficient, professional and accommodating.
Lisa E.
Dr. Jennifer Abbot was very friendly, caring, personable and efficient. check in was easy, short wait time, in and out.
Lisa E.
Excelente trato de todos los profesionales desde la recepción hasta el doctor
Lisa E.
I recently visited Dr. Nina Schram for my son’s dermatology appointment, and I cannot speak highly enough about the experience. She was incredibly kind, patient, and attentive—she truly listened to all of my sons concerns and immediately provided a clear, effective treatment plan. Her entire staff was just as wonderful. From the moment we walked in, everyone was welcoming and professional. The nurse who assisted us was especially sweet and gentle, which made the whole visit so much easier and comforting for my son. Thank you so much, Dr. Schram, for your compassion and exceptional care. We are truly grateful.
Lisa E.
I love Dr Gamber. She has been my doctor for years and has always been easy to work with taking care of my aging skin!
Lisa E.
This place is amazing I got a same day appointment the MA worked tirelessly to get my insurance approval for my medications. They are truly a Godsend when you are tired of the run around of all the other Drs and you need to get help
Lisa E.
Excellent experience. Staff is friendly and the doctor if very thorough and comprehensive with her explanations. I have been a patient there for several years and will continue going there.
Lisa E.
Professional, caring, informative and knowledgeable! I work in the healthcare field and was impressed. I would highly recommend
Lisa E.
Derm treatments. I am a regular patient and visitor because of years of sun exposure. I am always impressed with the expertise, professionalism and the kind and caring attitude of the Fairfax Va center staff, especially Dr. Montemarano who has years of specialized experience and is a caring and gracious physician. I also appreciated seeing Carla, Martha and Sophio on my last visit among other amazing staff in the Fairfax, VA office!
Lisa E.
They did there big one I’m looking and feeling much better
Lisa E.
Awesome experience with my provider and the staff at the clinic. Highly recommend
Lisa E.
This was my second visit with Dr Jon Smith, surgeon. He was professional, knowledgeable, and friendly. His staff was excellent too. Highly recommend, and would definitely return if needed.
Lisa E.
Hannah Rose was so nice. She made it so easy and comfortable. A full body scan for skin cancer is not something anyone wants to do, but she made it so easy and painless. Thank you! Second appointment: Dr. Dawn and her assistant Cameron were absolutely amazing! So kind and friendly, putting me at ease, while also staying professional and doing an amazing job. I appreciated this entire office for making this experience easy for me. I am so grateful.
Lisa E.
All of my skin issues are addressed. Any concerns are always listened to.
Lisa E.
This is an excellent provider. My needs are always met by their personnel. I highly recommend Audrey Echt Dermatology and Skin Cancer Center to those looking for quality care.
Lisa E.
Great experience at East Tennessee Dermatology Group, Alcoa location. Very efficient. Highly recommend!
Lisa E.
I had a lifelong red spot near my eye and got it removed by Provider Henry Yan quickly and painlessly. He was very gentle & professional, I should’ve had this removed decades ago! Thank you!
Lisa E.
Very attentive and caring medical team. Dr. Katz has a lot of patience and would offer to take care of issues on the spot if possible. Will always give you options and his team always follow up. Easy free parking right next door to his medical office.
Lisa E.
Friendly staff , great atmosphere
Lisa E.
Fast and knowledgeable
Lisa E.
My visits are for skin cancer screenings because of my history. I visit the Charlotte/pineville area location specifically to see Dr April B******. I’ve been to several dermatologists because of insurance network parameters and was very happy finding out that she was at a facility in my current network. She is really good at what she does. Thanks
Lisa E.
Dr. Prussick precisely answers each question, so go prepared with a list of specific questions and concerns. Not abruptly but without wasting your or his time.
Lisa E.
Very professional and informative. Clean and sterile office and they didn’t rush my visit which was appreciated.
Lisa E.
Great staff! Great doctor!!
Lisa E.
Great experience, made my son be at ease and explained everything very clearly.
Lisa E.
Great experience. The staff and Doctor were more than accommodating and made me feel at ease.
Lisa E.
Always fast. Super friendly staff.
Lisa E.
I am totally satisfied with his medical examinations. However, trying to get in touch by phone became a horror show since he became part of the larger group. The first call said there was a 39 minute wait time. I was able to leave a message to be called later. I was unable to answer the return call, but a message was left on my machine. Unfortunately, the message started skipping and I could not hear all of the new phone number to be called. My second call soon got the recorded message announcing the wait time as one minute. It then kept repeating the one minute wait time message over and over and over. After 5 minutes of this, I hung up. On my third try, the recording said over and over and over that the wait time was the 8 minutes. After getting frustrated again, I was about to hang up when suddenly the call was answered--by a lady who sounded very, very bored with her job.
Lisa E.
Angie is a gem! Whoever brought her on board, kudos to you.👏🏾My 2 teenage daughters have been patients here for a few years and on each & every visit, she is always so sweet, kind, relatable and welcoming. That really goes a long way. ❤️
Lisa E.
I can't speak highly enough about my experience at Academic alliance! From the moment I walked in, I felt genuinely cared for, not just as a patient, but as a person. The front desk ladies are welcoming and incredibly attentive. Every step of the process, from check in to follow up, was handled with professionalism and kindness. What truly sets this practice apart is their compassion. Frankie took the time to listen carefully to my concerns, explain my condition in clear, reassuring terms, and create a personalized treatment plan that made me feel confident and supported. I never felt rushed or like just another appointment on the calendar. The entire team is thoughtful, respectful, and clearly passionate about helping people feel their best. Whether you're dealing with a complex skin condition or a routine check (even BOTOX!!!) you’ll be met with the same level of care and empathy. If you’re looking for expert dermatologic care delivered with heart, this is the place to go. I’m so grateful to have found them!
Lisa E.
Please let me express my gratitude to Dr. Wu. I had Vbeam lasers and Kenalog injections for my skin issues, and I’ve seen great improvements. Dr. Wu is very skillful in these procedures and answered all my questions with patience. It was a great treatment experience, and the staff are friendly as well. Highly recommended.
Lisa E.
Everyone is so kind and Ms. McLaughlin is so kind and explains everything.
Lisa E.
Very professional and friendly team - exceptional experience here - very highly recommend!
Lisa E.
Dr. Harris was absolutely amazing! She was incredibly personable, kind, and took the time to thoroughly answer all of my questions without making me feel rushed. As a first-time mom, I really appreciated how gentle and reassuring she was with my son, and I left feeling confident in his care and treatment plan. As a first-time mom, I really appreciated how patient, gentle, and reassuring everyone was. Thank you for taking such great care of my son!!! We highly recommend this practice to anyone looking for a knowledgeable and compassionate dermatologist!
Lisa E.
Nurse Harris and her staff are awesome, very knowledgeable and kind. I highly recommend Harris.
Lisa E.
First time ever getting any cosmetic work done I was nervous and excited. But Dr Dan was super comforting and walked me thru everything before doing it. He also took interest in what I wanted to look like and decided on the best option for me. I love it and will return for more in the future!
Lisa E.
Fantastic experience from the front desk, nurse assistant Dr. Becker. I highly recommend.
Lisa E.
Dr Lam and his team are extremely professional, kind and helpful. Highly recommended!
Lisa E.
Here’s a revised version: I had an excellent experience at Academic Alliance in Dermatology West Largo. I was there today to have my second squamous cell carcinoma removed from my scalp, as well as another one removed from my leg. The building is brand new, exceptionally clean, and very welcoming. Everyone on the staff was professional, friendly, and genuinely caring from the moment I arrived. The doctors and staff took the time to answer my questions, explain the procedures, and make me feel comfortable throughout my visit. Their attention to detail and commitment to patient care were outstanding. I highly recommend Academic Alliance in Dermatology West Largo to anyone looking for high-quality dermatology care. Thank you to the entire team for making what could have been a stressful day such a positive experience.
Lisa E.
Dr. Momtemarano was amazing. One of the best doctor experiences I've had.... ever. I went in for a potentially unpleasant experience, a cancer biopsy of a badly discolored pinkie toe nail, which I was told beforehand would involve drilling into it or removal of the entire nail. In the end, he did pry off and pull out the entire nail and then slice into the tissue underneath to get a biopsy sample. The thing that hurt the most was the anaesthesia injection. Despite the invasiveness of it all, my primary experience of it was, "wow, what a confident, competent, calming and friendly presence this doctor is!" He has a super warm bedside manner, as well as an extraordinary ability to explain complex things, listen actively and respond, and instill a sense of comfort. He was great. I'd go back in tomorrow to have another toenail removed just for the good conversation.
Lisa E.
Professional, friendly, and they listen. I always feel in good hands
Lisa E.
Great service by the Staff and doctors
Lisa E.
Amazing team! Very attentive and caring
Lisa E.
I NEVER write a review… However, what an exceptional experience my husband and I had today. We were greeted with smiles and such a knowledgeable staff/practice. If I could give a 10 ⭐️ I would. Dr Hand was WONDERFUL, warm and welcoming and her Nurse Coni was just a love!!! Oh…and the office is super beautiful and pristine. Thank you to everyone here for making our experience so fantastic!
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Lisa E.
Your Chemotherapy Questions, Answered
No, and this distinction matters. The chemotherapy used in oncology is systemic: it is administered intravenously or orally and travels through the entire body to target cancer cells wherever they may be. Topical chemotherapy in dermatology is applied directly to the surface of the skin and works only in the area where it is applied. It does not enter the bloodstream in meaningful amounts and is not associated with the systemic side effects that most people associate with traditional chemotherapy.
The two most commonly prescribed topical chemotherapy agents in dermatology are 5-fluorouracil, available under brand names including Efudex and Carac, and imiquimod, available as Aldara or Zyclara. Both are prescription medications. 5-FU works by blocking the ability of abnormal cells to replicate. Imiquimod works differently. It activates the immune system to identify and eliminate abnormal cells. Your dermatologist will select the appropriate medication and formulation based on your specific diagnosis.
Topical chemotherapy is most commonly used to treat actinic keratoses, or precancerous, rough, sun-damaged patches that can progress to squamous cell carcinoma if left untreated. It is also used for superficial basal cell carcinoma and squamous cell carcinoma in situ in areas appropriate for non-surgical treatment. It is particularly well-suited for treating field damage, broad areas of sun-injured skin with multiple visible and subclinical lesions.
A significant inflammatory skin reaction is a normal and expected part of topical chemotherapy. As treatment progresses, the treated area typically becomes red, swollen, and may crust, blister, or feel raw. This reaction can look alarming if you are not prepared for it, which is why your provider will explain exactly what to expect before you begin. The reaction indicates that the medication is working. If you experience severe pain, signs of infection, or a reaction outside the treatment area, contact your provider.
Most patients can maintain their normal routine during treatment, though you may want to avoid situations where the treated area will be prominently visible or exposed to the sun. Sun protection over the treated area is important throughout the course. Your provider will advise you on any specific activity restrictions based on the location being treated.
The duration varies by medication and diagnosis. A standard course of 5-fluorouracil is typically two to four weeks of daily or twice-daily application. Imiquimod regimens may span several weeks with application on alternating days. Full healing after completing the treatment course generally takes an additional four to eight weeks. Your provider will give you a specific schedule at your consultation.
Yes, your provider will schedule follow-up visits during and after your treatment course to assess your skin's response, address any concerns, and confirm complete resolution once healing is complete. The frequency of follow-up visits will depend on your specific regimen and how your skin is responding.
If the inflammatory response becomes difficult to manage, contact your provider before stopping treatment on your own. In some cases, a brief treatment pause or adjustment to the application schedule can help. Stopping early may reduce effectiveness, so it is important to communicate with your care team rather than discontinue without guidance.
Topical chemotherapy is highly effective for the right candidates and the right diagnoses, but it is not appropriate for all skin cancers or all patients. Response rates vary, and some patients may require additional treatment after completing a topical course. Your provider will evaluate your results at follow-up and recommend any further treatment if needed.
Ready to address your skin cancer concerns?
Our team builds a plan around you. Schedule now to alleviate your skin cancer concerns.
Related Treatments
Precancerous Skin Deserves Expert Attention
Actinic keratoses and early-stage skin cancers are highly treatable, and addressing them before they progress is always the right call. Our board-certified dermatologists will evaluate your skin, explain your options clearly, and recommend a treatment plan that fits your diagnosis and your life.
